Ruthenium‐Catalyzed Enantioselective Propargylic Phosphinylation of Propargylic Alcohols with Phosphine Oxides

Abstract The development of transition metal‐catalyzed enantioselective propargylic substitution reactions has gained much progress in recent years, however, no successful example with phosphorus‐centered nucleophiles has yet been reported until now. Herein, we report the first successful example of ruthenium‐catalyzed enantioselective propargylic substitution reactions of propargylic alcohols with diarylphosphine oxides as phosphorus‐centered nucleophiles. This synthetic approach provides a new method to prepare chiral phosphorus‐containing organic compounds.