机制(生物学)
氯胺酮
神经科学
NMDA受体
AMPA受体
谷氨酸受体
作用机理
神经营养因子
突触可塑性
PI3K/AKT/mTOR通路
神经可塑性
药理学
医学
心理学
受体
信号转导
生物
内科学
认识论
哲学
体外
生物化学
作者
Muhammad Asim,Bing Wang,Bo Hao,Xiaoguang Wang
标识
DOI:10.1016/j.neuint.2021.105044
摘要
Posttraumatic stress disorder (PTSD) is a devastating medical illness, for which currently available pharmacotherapies have poor efficacy. Accumulating evidence from clinical and preclinical animal investigations supports that ketamine exhibits a rapid and persistent effect against PTSD, though the underlying molecular mechanism remains to be clarified. In this literature review, we recapitulate the achievements from early ketamine studies to the most up-to-date discoveries, with an effort to discuss an inclusive therapeutic role of ketamine for PTSD treatment and its possible therapeutic mechanism. Ketamine seems to have an inimitable mechanism of action entailing glutamate modulation via actions at the N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors, as well as downstream activation of brain-derived neurotrophic factor (BDNF) and mechanistic target of rapamycin (mTOR) signaling pathways to potentiate synaptic plasticity.
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