Structural and in vitro biological evaluation of sol-gel derived multifunctional Ti+4/Sr+2 co-doped bioactive glass with enhanced properties for bone healing

傅里叶变换红外光谱 扫描电子显微镜 模拟体液 核化学 材料科学 感应耦合等离子体 光谱学 等离子体原子发射光谱 碱性磷酸酶 分析化学(期刊) 红外光谱学 能量色散X射线光谱学 生物活性玻璃 兴奋剂 溶胶凝胶 矿物学 化学 化学工程 纳米技术 色谱法 复合材料 生物化学 有机化学 物理 工程类 等离子体 量子力学 光电子学
作者
Amirhossein Moghanian,Saba Nasiripour,Zahra Miri,Zeinab Hajifathali,Seyed Hesamedin Hosseini,Mohammad Sajjadnejad,Roozbeh Aghabarari,Noushin Nankali,Amir K. Miri,Mohammadreza Tahriri
出处
期刊:Ceramics International [Elsevier BV]
卷期号:47 (20): 29451-29462 被引量:13
标识
DOI:10.1016/j.ceramint.2021.07.113
摘要

The principal focus of this study was to evaluate the effect of different strontium (Sr) percentages substitution (Sr content = 0, 1, 3, 6, 9, and 12 mol. %) and fixed 5 mol. % titanium (Ti) in bioactive glass (T-BG) in terms of in vitro biological, bactericidal, and structural behaviors of SiO2-60%, CaO-(31-x)%, P2O5-4%, TiO2-5%, SrO-X% (mol. %) TS-BG. The structural analysis of BGs specimens containing Ti and Sr was performed by scanning electron microscopy (SEM), X-ray diffraction (XRD), Energy-dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectrum (FTIR), Transmittance electron microscopy (TEM), and Inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analyses. The alkaline phosphatase (ALP) activity test and 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analysis were also conducted to investigate in vitro biological behavior of TS-BGs. Meanwhile, the bactericidal efficiency of TS-BGs against MRSA was examined. The SEM results indicated that hydroxyapatite (HA) appeared on TS-BGs' surface after one and two weeks of immersion in the simulated body fluid (SBF). HA characteristic peaks in XRD patterns as well as P–O and C–O bands in FTIR spectra confirmed the in vitro bioactivity. A similar trend in altering MC3T3 cell proliferation and cell differentiation was observed by increasing Sr amount up to 6 mol. %. Then, it had a downward trend up to 12 mol. % Sr. Meanwhile, the more Sr amounts added, the more TS-BGs antibacterial activity was achieved, and the specimen with 12 mol. % Sr and fixed 5 mol. % Ti (TS12) showed 34.27% bactericidal efficiency more than the control specimen (TS0). Taken together, the specimen with 6 mol.% Sr and fixed 5 mol. % Ti (TS6) was chosen as an optimal specimen among the other synthesized TS-BGs because of its higher in vitro bioactivity (HA forming ability after 7 days), MC3T3 cell proliferation, differentiation, and bactericidal efficiency than other specimens.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
1秒前
乐乐应助健忘英姑采纳,获得10
3秒前
嗯嗯发布了新的文献求助10
3秒前
4秒前
Wangyicong完成签到,获得积分10
5秒前
Lucas应助科研通管家采纳,获得10
6秒前
萧水白应助科研通管家采纳,获得10
6秒前
Lucas应助科研通管家采纳,获得10
6秒前
田様应助科研通管家采纳,获得10
6秒前
大模型应助科研通管家采纳,获得10
6秒前
大模型应助科研通管家采纳,获得10
6秒前
bkagyin应助科研通管家采纳,获得30
6秒前
科研通AI2S应助科研通管家采纳,获得10
6秒前
FashionBoy应助科研通管家采纳,获得10
6秒前
6秒前
6秒前
萧水白应助科研通管家采纳,获得10
6秒前
6秒前
6秒前
6秒前
阿腾发布了新的文献求助10
7秒前
FloppyWow完成签到 ,获得积分10
8秒前
xn201120发布了新的文献求助150
8秒前
舒心的依风完成签到,获得积分10
9秒前
嗯嗯完成签到,获得积分10
10秒前
baba发布了新的文献求助10
11秒前
胡庆余堂小洋参完成签到,获得积分10
11秒前
Akim应助义气萝卜头采纳,获得10
13秒前
眼睛大寻双完成签到,获得积分20
14秒前
Orange应助兴奋雁蓉采纳,获得10
15秒前
猪猪hero应助ElbingX采纳,获得20
17秒前
18秒前
18秒前
19秒前
好旺完成签到,获得积分10
22秒前
CC关闭了CC文献求助
22秒前
深情安青应助霸气安筠采纳,获得20
23秒前
思源应助htx采纳,获得30
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976267
求助须知:如何正确求助?哪些是违规求助? 3520472
关于积分的说明 11203425
捐赠科研通 3257089
什么是DOI,文献DOI怎么找? 1798589
邀请新用户注册赠送积分活动 877785
科研通“疑难数据库(出版商)”最低求助积分说明 806523