Structural and in vitro biological evaluation of sol-gel derived multifunctional Ti+4/Sr+2 co-doped bioactive glass with enhanced properties for bone healing

傅里叶变换红外光谱 扫描电子显微镜 模拟体液 核化学 材料科学 感应耦合等离子体 光谱学 等离子体原子发射光谱 碱性磷酸酶 分析化学(期刊) 红外光谱学 能量色散X射线光谱学 生物活性玻璃 兴奋剂 溶胶凝胶 矿物学 化学 化学工程 纳米技术 色谱法 复合材料 生物化学 有机化学 物理 工程类 等离子体 量子力学 光电子学
作者
Amirhossein Moghanian,Saba Nasiripour,Zahra Miri,Zeinab Hajifathali,Seyed Hesamedin Hosseini,Mohammad Sajjadnejad,Roozbeh Aghabarari,Noushin Nankali,Amir K. Miri,Mohammadreza Tahriri
出处
期刊:Ceramics International [Elsevier BV]
卷期号:47 (20): 29451-29462 被引量:13
标识
DOI:10.1016/j.ceramint.2021.07.113
摘要

The principal focus of this study was to evaluate the effect of different strontium (Sr) percentages substitution (Sr content = 0, 1, 3, 6, 9, and 12 mol. %) and fixed 5 mol. % titanium (Ti) in bioactive glass (T-BG) in terms of in vitro biological, bactericidal, and structural behaviors of SiO2-60%, CaO-(31-x)%, P2O5-4%, TiO2-5%, SrO-X% (mol. %) TS-BG. The structural analysis of BGs specimens containing Ti and Sr was performed by scanning electron microscopy (SEM), X-ray diffraction (XRD), Energy-dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectrum (FTIR), Transmittance electron microscopy (TEM), and Inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analyses. The alkaline phosphatase (ALP) activity test and 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analysis were also conducted to investigate in vitro biological behavior of TS-BGs. Meanwhile, the bactericidal efficiency of TS-BGs against MRSA was examined. The SEM results indicated that hydroxyapatite (HA) appeared on TS-BGs' surface after one and two weeks of immersion in the simulated body fluid (SBF). HA characteristic peaks in XRD patterns as well as P–O and C–O bands in FTIR spectra confirmed the in vitro bioactivity. A similar trend in altering MC3T3 cell proliferation and cell differentiation was observed by increasing Sr amount up to 6 mol. %. Then, it had a downward trend up to 12 mol. % Sr. Meanwhile, the more Sr amounts added, the more TS-BGs antibacterial activity was achieved, and the specimen with 12 mol. % Sr and fixed 5 mol. % Ti (TS12) showed 34.27% bactericidal efficiency more than the control specimen (TS0). Taken together, the specimen with 6 mol.% Sr and fixed 5 mol. % Ti (TS6) was chosen as an optimal specimen among the other synthesized TS-BGs because of its higher in vitro bioactivity (HA forming ability after 7 days), MC3T3 cell proliferation, differentiation, and bactericidal efficiency than other specimens.
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