Mn(OAc)3 Induced C-4 Arylations of Quinazoline 3-Oxides with Arylboronic Acids

Abstract The use of manganese triacetate as an oxidant component in the C-4 arylations of 2-aryl-quinazoline 3-oxides with arylboronic acids­ is reported. The new protocol was applied to prepare new 2,4-di­arylated quinazoline 3-oxides in good to high yields. The method was shown to tolerate various substituents on both aromatic rings, and no complications such as deoxygenation or rearrangement to quinazolin-4(3H)-one was observed.