过氧化氢
肿瘤微环境
催化作用
化学
过氧化物酶
激进的
体内
生物物理学
活性氧
纳米颗粒
辣根过氧化物酶
羟基自由基
交货地点
肿瘤细胞
癌症研究
纳米技术
生物化学
酶
材料科学
生物
生物技术
农学
作者
Danyang Liang,Yongzhen Yang,Gongjian Li,Qian Wang,Heting Chen,Xiaoyuan Deng
出处
期刊:Materials
[Multidisciplinary Digital Publishing Institute]
日期:2021-04-13
卷期号:14 (8): 1933-1933
被引量:9
摘要
Nanozymes are emerging as a promising strategy for the treatment of tumors. Herein, to cope with the tumor microenvironment (TME), weak acidity (pH 5.6 to 6.8) and trace amounts of overexpressed hydrogen peroxide (H2O2) (100 µM–1 mM), we report nitrogen-doped graphene nanomaterials (N-GNMs), which act as highly efficient catalytic peroxidase (POD)-mimicking nanozymes in the TME for tumor-specific treatment. N-GNMs exhibit POD catalytic properties triggered by a weakly acidic TME and convert H2O2 into highly toxic hydroxyl radicals (•OH) thus causing the death of tumor cells while in the neutral pH surroundings of normal tissues, such catalysis is restrained and leaves normal cells undamaged thereby achieving a tumor-specific treatment. N-GNMs also display a high catalytic activity and can respond to the trace endogenous H2O2 in the TME resulting in a high efficiency of tumor therapy. Our in vitro chemical and cell experiments illustrated the POD-like activity of N-GNMs and in vivo tumor model experiments confirmed the significant inhibitory effect of N-GNMs on tumor growth.
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