Mesoporous zirconia surfaces with anti-biofilm properties for dental implants

介孔材料 材料科学 生物膜 X射线光电子能谱 立方氧化锆 核化学 生物活性玻璃 化学工程 复合材料 细菌 化学 有机化学 催化作用 陶瓷 冶金 工程类 生物 遗传学
作者
Agnese D’Agostino,Francesca Tana,Alessandro Ettorre,Matteo Pavarini,Andrea Serafini,Andrea Cochis,Alessandro Calogero Scalia,Lia Rimondini,Elvira De Giglio,Stefania Cometa,Roberto Chiesa,Luigi De Nardo
出处
期刊:Biomedical Materials [IOP Publishing]
卷期号:16 (4): 045016-045016 被引量:12
标识
DOI:10.1088/1748-605x/abf88d
摘要

Cytocompatible bioactive surface treatments conferring antibacterial properties to osseointegrated dental implants are highly requested to prevent bacteria-related peri-implantitis. Here we focus on a newly designed family of mesoporous coatings based on zirconia (ZrO2) microstructure doped with gallium (Ga), exploiting its antibacterial and pro-osseo-integrative properties. The ZrO2films were obtained via sol-gel synthesis route using Pluronic F127 as templating agent, while Ga doping was gained by introducing gallium nitrate hydrate. Chemical characterization by means of x-ray photoelectron spectroscopy and glow discharge optical emission spectroscopy confirmed the effective incorporation of Ga. Then, coatings morphological and structural analysis were carried out by transmission electron microscopy and selected area electron diffraction unveiling an effective stabilization of both the mesoporous structure and the tetragonal ZrO2phase. Specimens' cytocompatibility was confirmed towards gingival fibroblast and osteoblasts progenitors cultivated directly onto the coatings showing comparable metabolic activity and morphology in respect to controls cultivated on polystyrene. The presence of Ga significantly reduced the metabolic activity of the adhered oral pathogensPorphyromonas gingivalisandAggregatibacter actinomycetemcomitansin comparison to untreated bulk zirconia (p< 0.05); on the opposite, Ga ions did not significantly reduce the metabolism of the oral commensalStreptococcus salivarius(p> 0.05) thus suggesting for a selective anti-pathogens activity. Finally, the coatings' ability to preserve cells from bacterial infection was proved in a co-culture method where cells and bacteria were cultivated in the same environment: the presence of Ga determined a significant reduction of the bacteria viability while allowing at the same time for cells proliferation. In conclusion, the here developed coatings not only demonstrated to satisfy the requested antibacterial and cytocompatibility properties, but also being promising candidates for the improvement of implantable devices in the field of implant dentistry.
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