PET Imaging of Meningioma Using the Novel SSTR-Targeting Peptide 18F-SiTATE

Abstract PET using 68 Ga-labeled somatostatin receptor (SSTR) ligands adds significant information in meningioma patients. 18 F-SiTATE is a novel, 18 F-labeled SSTR-targeting peptide with remarkable imaging properties. Here, we present a 72-year-old woman with falx meningioma and transosseous extension. 18 F-SiTATE PET/CT was performed 12 months after the previous 68 Ga-DOTATOC PET/CT with comparable quantitative uptake and very good spatial resolution. So far, the widespread use of SSTR ligands for NET and meningioma imaging is hampered by cost-intensive 68 Ge/ 68 Ga generators, low activity amounts, lower spatial resolution, and short half-life. 18 F-SiTATE might foster widespread use of SSTR ligands, overcoming the shortcomings of 68 Ga-labeled ligands.