材料科学
介电谱
纳米复合材料
循环伏安法
分子印迹聚合物
微分脉冲伏安法
电极
电化学气体传感器
化学工程
扫描电子显微镜
傅里叶变换红外光谱
纳米技术
电化学
选择性
化学
复合材料
有机化学
工程类
物理化学
催化作用
作者
Mohammad Mehmandoust,Nevin Erk,Ceren Karaman,Onur Karaman
出处
期刊:Chemosphere
[Elsevier]
日期:2022-03-01
卷期号:291: 132807-132807
被引量:74
标识
DOI:10.1016/j.chemosphere.2021.132807
摘要
The molecularly imprinted polymers (MIP) is an outstanding electrochemical tool that demonstrates good chemical sensitivity and stability. These main advantages, coupled with the material's vast microfabrication flexibility, make molecularly imprinted sensors an attractive sensing device. Herein, it was aimed to develop a state-of-art molecularly imprinted sensor based on CuBi2O4/rGO@MoS2 nanocomposite to be utilized for the detection of linagliptin (LNG), a novel hypoglycemic drug. The electrochemical characterizations of linagliptin on the surface of the modified electrode was examined via cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). Several characterization methods including transmission electron microscope (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and Energy-dispersive X-ray spectroscopy(EDX), were utilized for electrode characterization. The LNG imprinted voltammetric sensor was developed in 80.0 mM phenol containing 20.0 mM LNG. CuBi2O4/rGO@MoS2 nanocomposite on LNG imprinted screen-printed carbon electrode (SPCE) (MIP/CuBi2O4/rGO@MoS2 nanocomposite/SCPE) exhibited a linear relationship between peak current and LNG concentration in the range 0.07-0.5 nM with a detection limit of 0.057 nM. In the existence of interfering substances, an LNG imprinted electrode was utilized to analyze urine, human plasma, and tablet samples with adequate selectivity. The developed sensor was also illustrated for stability, repeatability, reproducibility, and reusability.
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