脂滴
生物
磷脂
脂质代谢
胆碱
细胞生物学
脂质积聚
酵母
化学
细胞内
平衡
生物化学
膜
作者
Grzegorz Sienski,Priyanka Narayan,Julia Maeve Bonner,Nora Kory,Sebastian Boland,Aleksandra Arczewska,William T. Ralvenius,Leyla Anne Akay,Elana R. Lockshin,Liang He,Blerta Milo,Agnese Graziosi,Valeriya Baru,Caroline A. Lewis,M Kellis,David M. Sabatini,Li‐Huei Tsai,Susan Lindquist
出处
期刊：Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期：2021-03-03
卷期号：13 (583)
被引量：184
标识
DOI：10.1126/scitranslmed.aaz4564
摘要
APOE4 -disrupted intracellular lipid homeostasis in human and yeast cells was reversed by promoting phospholipid synthesis through choline supplementation.
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