神经科学
脊髓损伤
脊髓
连接体
医学
神经影像学
神经可塑性
生物神经网络
功能连接
心理学
作者
Lijian Zhang,Luxuan Wang,Hechun Xia,Yanli Tan,Chunhui Li,Chuan Fang
标识
DOI:10.1016/j.neures.2021.10.008
摘要
Following spinal cord injury (SCI), the central nervous system undergoes significant reconstruction. The dynamic change in the interaction of the brain-spinal cord axis as well as in structure-function relations plays a vital role in the determination of neurological functions, which might have important clinical implications for the treatment and its efficacy evaluation of patients with SCI. Brain connectomes based on neuroimaging data is a relatively new field of research that maps the brain's large-scale structural and functional networks at rest. Importantly, increasing evidence shows that such resting-state signals can also be seen in the spinal cord. In the present review, we focus on the reconstruction of multi-level neural circuits after SCI. We also describe how the connectome concept could further our understanding of neuroplasticity after SCI. We propose that mapping the cortical-subcortical-spinal cord networks can provide novel insights into the pathologies of SCI.
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