Systematic analysis of experimental and clinical pharmacology of micronized progesterone preparations

Micronization of progesterone is necessary for improving the pharmacokinetic properties of progestin preparations that increase the chances of favorable pregnancy outcomes and are essential for hormone replacement therapy. A computer analysis of 637 publications on micronized progesterone (MP) made it possible to systematize the results of studies (1) on the pharmacokinetics of MP preparations, (2) the use of MP in therapy for hot flashes, (3) the effect of MP on the central nervous system, (4) the normolipidemic properties of MP, (5) the use of MP to maintain pregnancy and (6) to improve the efficiency of reproductive technologies. Key words: safety issues, micronized progesterone, pregnancy maintenance, Prajisan, pharmacoanalytics