The protective effects of quercetin nano-emulsion on intestinal mucositis induced by 5-fluorouracil in mice

粘膜炎 槲皮素 乳状液 药理学 抗氧化剂 化学 不利影响 类黄酮 医学 化疗 生物化学 内科学
作者
Mandana Lotfi,Sohrab Kazemi,Fatemeh Shirafkan,Rezvan Hosseinzadeh,Anahita Ebrahimpour,Mohammad Barary,Terence T. Sio,Seyed Mohammad Hosseini,Ali Akbar Moghadamnia
出处
期刊:Biochemical and Biophysical Research Communications [Elsevier BV]
卷期号:585: 75-81 被引量:19
标识
DOI:10.1016/j.bbrc.2021.11.005
摘要

Intestinal mucositis is one of chemotherapeutics' most common adverse effects, such as 5-fluorouracil (5-FU). Quercetin (QRC), a naturally occurring flavonoid, has approved antioxidant and anti-inflammatory properties. Thus, in this article, the preventive and curative effects of emulsion and nano-emulsion formulations of QRC were investigated in a model of 5-FU-induced intestinal mucositis using biochemical, histopathological, and molecular approaches.Thirty-six mice were divided into six different groups: Control (normal saline), 5-FU (a single dose of 5-FU 300 mg/kg), pre-treatment groups (pre-QRC, and pre-QRC-nano, receiving QRC 5 mg/kg emulsion and nano-emulsion before the induction of mucositis, respectively), and post-treatment groups (post-QRC, and post-QRC-nano, receiving QRC 5 mg/kg emulsion and nano-emulsion after the induction of mucositis, respectively).The administration of quercetin emulsion and nano-emulsion could significantly alleviate the oxidant-antioxidant balance of mice serum samples and reverse the destructive histopathologic changes induced by 5-FU in the intestine tissue. Nevertheless, although the expression of both pro-inflammatory genes, NF-κB and HIF-1α, was decreased when quercetin was administered to mice, this reduction was not statistically significant.The administration of quercetin emulsion and nano-emulsion formulations could ameliorate the oxidative damage induced by chemotherapeutics, such as the 5-FU. Therefore, if confirmed in further studies, it could be used in clinical settings as a preventive and curative agent to decrease such catastrophic adverse events in chemotherapy patients.
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