行为绝望测验
社会失败
原肌球蛋白受体激酶B
药理学
抗抑郁药
丙咪嗪
人参
MAPK/ERK通路
蛋白激酶B
海马结构
神经发生
脑源性神经营养因子
奶油
尾部悬挂试验
神经营养因子
氟西汀
神经保护
内分泌学
医学
内科学
海马体
信号转导
化学
心理学
神经科学
受体
生物化学
血清素
替代医学
病理
基因
转录因子
作者
Ning Jiang,Hong Huang,Yiwen Zhang,Jingwei Lv,Qiong Wang,Qinghu He,Xinmin Liu
标识
DOI:10.3389/fphar.2021.680903
摘要
Ginsenoside Rb1 (Rb1), an important bioactive ingredient of Panax ginseng, has potent neuroprotective effects. The objective of the study is to elucidate the impact of Rb1 treatment on chronic social defeat stress (CSDS)-induced depressive-like behaviors and its related mechanism. According to the obtained results, the daily oral administration of Rb1 (35 and 70 mg/kg) and imipramine (15 mg/kg) for 28 days significantly reversed the social avoidance behavior, anhedonia, and behavioral despair via CSDS exposure, as demonstrated by the considerable elevation in the time in the zone in the social interaction test, consumption of sucrose solution in the sucrose preference test, and decrease in immobility time in the forced swim test. Moreover, Rb1 obviously restored the CSDS-induced decrease in the BDNF signaling pathway and hippocampal neurogenesis. Rb1 significantly increased the hippocampal levels of ERK, AKT, and CREB phosphorylation and increased the number of DCX+ cells in DG. Importantly, the antidepressant effects of Rb1 were completely blocked in mice by using K252a (the nonselective tyrosine kinase B inhibitor). In conclusion, our results indicated that Rb1 exerts promising antidepressant-like effects in mice with CSDS-induced depression, and its effects were facilitated by enhancing the BDNF signaling cascade and upregulation of hippocampal neurogenesis.
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