心情
脑源性神经营养因子
心理学
全基因组关联研究
情绪障碍
双相情感障碍
遗传关联
神经营养因子
多态性(计算机科学)
遗传学
肿瘤科
临床心理学
内科学
医学
单核苷酸多态性
基因型
精神科
生物
基因
受体
焦虑
作者
Ming Li,Hong Chang,Xiao Xiao
标识
DOI:10.1016/j.neubiorev.2016.05.031
摘要
Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-like effects in animal models and may be implicated in the etiology of mood-related phenotypes. A functional polymorphism (Val66Met) in the BDNF gene was demonstrated to influence BDNFs secretion and function, as well as mood and cognitive related phenotypes. However, previous genetic association studies of Val66Met polymorphism in the clinical risk of mood disorders have been complicated, possibly due to phenotypic diversity, underpowered statistical association or ancestry-specific effects. Here, we collected mood phenotypic and genetic data in over 90,000 individuals from diverse ethnic groups and conducted a systematic meta-analysis. The results showed that the Val66Met polymorphism was significantly associated with BPD in Europeans (Pmeta = 0.0029, OR = 1.136), but not in Asians (Pmeta = 0.443). Also, it appears that the risk for MDD conferred by BDNF is waning, as the Val66Met variant was not associated with MDD in either European or Asian samples (Pmeta > 0.5).
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