化学
奥司他韦
组合化学
全合成
立体化学
2019年冠状病毒病(COVID-19)
内科学
医学
传染病(医学专业)
疾病
作者
Yujiro Hayashi,Shin Ogasawara
出处
期刊:Organic Letters
[American Chemical Society]
日期:2016-07-05
卷期号:18 (14): 3426-3429
被引量:70
标识
DOI:10.1021/acs.orglett.6b01595
摘要
A time economical 60 min total synthesis of (−)-oseltamivir was accomplished in a single reaction vessel over five steps. One of the key issues is reduction in the number of steps by eliminating lengthy reaction steps with substitution of a rapid epimerization step. A catalytic system consisting of three reagents, namely, diphenylprolinol silyl ether, thiourea, and acid, was developed for a rapid asymmetric Michael reaction with excellent diastereo- and enantioselectivities. All reactions were optimized in terms of not only yield and selectivity but also reaction time.
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