医学
结直肠癌
外科
新辅助治疗
B组
临床试验
随机对照试验
完全响应
化疗
癌症
内科学
乳腺癌
作者
Ramakrishnan Ayloor Seshadri,Satish S Kondaveeti,Sunil Bhanu Jayanand,Alexander John,Rejiv Rajendranath,Vasanthi Arumugam,Hemanth Raj Ellusamy,Tenali Gnana Sagar
出处
期刊:PubMed
日期:2013-05-01
卷期号:60 (123): 410-4
被引量:42
摘要
Neoadjuvant chemoradiation for rectal cancers may result in complete clinical response (cCR) in some patients. The aim of this study was to analyze the long-term outcomes of such patients in a tertiary cancer center.Patients with rectal cancer who had a cCR to neoadjuvant chemoradiation were divided into two groups: Group A (n=23) did not undergo surgery, and Group B (n=10) underwent elective surgery. The recurrence patterns and survival outcomes were compared between the two groups.After a median follow-up of 72 months (range 12-180), seven patients (30%) in Group A developed an isolated local recurrence. In Group B, after a median follow-up of 37 months (range 12-180) there were no local recurrences. The median disease-free and overall survival was 36 months (range 6-168) and 66 months (range 12-180) in Group A and 36 months (range 12-180) and 37 months (range 18-180) in Group B respectively.Our results suggest that surgery could be avoided in selected patients with rectal cancer who have a cCR to neoadjuvant chemoradiation. However, until the safety of a non-surgical approach is proven in a prospective randomized trial, it cannot be recommended outside a clinical protocol study.
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