衣壳
帽状体
基因组
生物
DNA
基因
二十面体对称
腺病毒科
病毒
计算生物学
结构相似性
乳腺腺病毒
低温电子显微
病毒学
分子生物学
化学
遗传学
生物物理学
遗传增强
结晶学
生物化学
作者
C. P. Martı́n,Roger M. Burnett
出处
期刊:Current Topics in Microbiology and Immunology
日期:2003-01-01
卷期号:: 57-94
被引量:39
标识
DOI:10.1007/978-3-662-05597-7_3
摘要
The adenovirus genome encodes more than 40 proteins, of which 11 combine with the viral DNA to form an icosahedral capsid of approximately 150 MDa molecular weight and approximately 900 A in diameter. This chapter reviews the information that structural biology techniques have provided about the adenovirus proteins and capsid. The structures of two capsid proteins (hexon and fiber) and two non-structural polypeptides (DNA-binding protein and protease) have been solved by X-ray crystallography. Fiber and its knob have been the focus of the latest structural studies, due to their role in host recognition and consequently in virus targeting for human gene therapy. The current model for the large capsid comes from a combination of electron microscopy and crystallography. The resultant images have revealed a surprising similarity between adenovirus and a bacterial virus, which suggests their common evolutionary origin.
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