Self-harm and suicidality in autism spectrum conditions (ASCs) have been underresearched. However, there is now convincing evidence that suicide is a leading cause of early death in the autistic community, and the prevalence of self-harm, suicidal thoughts, and suicidal behaviors is significantly elevated in autistic children and adults compared to the general population and psychiatric groups. Less research is currently available exploring the reasons why (etiology), how to assess or measure self-harm and suicidality, or how to treat these difficulties in autistic people. This chapter will summarize existing evidence on this topic and provide recommendations for future research and clinical practice to improve understanding, assessment, and prevention of self-harm and suicidality in ASD.