化学
扎尔鲁卡斯特
催化作用
蒙脱石
烷基化
产量(工程)
惰性气体
有机化学
介孔材料
弗里德尔-克拉夫茨反应
亲核取代
亲核芳香族取代
吲哚试验
受体
冶金
材料科学
敌手
生物化学
作者
Lei Yang,Xuan Chen,Kaidong Ni,Yuansheng Li,Jianhong Wu,Weilin Chen,Yin Ji,Lili Feng,Fēi Li,Dongyin Chen
标识
DOI:10.1016/j.tetlet.2020.152123
摘要
Proton-exchanged montmorillonite (H-mont) with outstanding surface characteristics can provide abundant acidic sites in the mesopores, and serve as an efficient heterogeneous catalyst for the synthesis of heterocycle-containing diarylmethanes via Friedel-Crafts-like alkylation of (hetero)arenes by heterobenzyl acetates under mild reaction conditions without requiring any additives or an inert atmosphere. Using this strategy, the gram-scale synthesis of indole-containing diarylmethane 13 has been accomplished in good yield for the preparation of Zafirlukast. In addition, H-mont can be applied to the nucleophilic substitution reactions of heterobenzyl acetate 5p with a variety of alcohols and 1,3-dicarbonyl compounds.
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