临床微生物学
基质辅助激光解吸/电离
临床诊断
鉴定(生物学)
样品制备
质谱法
色谱法
医学物理学
医学
化学
微生物学
解吸
生物
重症监护医学
吸附
有机化学
植物
出处
期刊:Chinese Journal of Laboratory Medicine
日期:2018-08-11
卷期号:41 (8): 559-562
标识
DOI:10.3760/cma.j.issn.1009-9158.2018.08.001
摘要
MALDI-TOF MS is a revolutionary and innovative technologyin clinical microbiological diagnosis. Due to its advantages of speed, specificity and ease of operation, MALDI-TOF MS has been rapidly accepted and approved by clinical laboratory. However, many challenges appeared when applied in clinical application. For example, sample preparation needs to be further optimized. Identification techniques have limitations. The quality improvement of database and the diversity of microbial species are still under discussion.The application of antimicrobial susceptibility testing is still controversial.The way ofrare identification resultstransmitting into clinical treatment is still being explored. But the application of MALDI-TOF MS in clinical microbiological diagnosis still needs to be improved.(Chin J Lab Med, 2018, 41: 559-562)
Key words:
Spectrometry, mass, matrix-Assisted laser desorption-ionization; Microbiological techniques; Clinical laboratory techniques
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