生物相容性
脚手架
材料科学
静电纺丝
复合数
生物医学工程
超细纤维
组织工程
明胶
复合材料
聚合物
化学
生物化学
医学
冶金
作者
Wenjie Ye,Chaoqi Xie,Yande Liu,Yong He,Qing Gao,Aiguo Ouyang
标识
DOI:10.1177/0885328220962606
摘要
Melt electrowriting (MEW) can print high-resolution scaffolds with the ultrafine fibers from 800 nm to 20 µm. However, the cell seeding efficiency relatively low due to the large pore size of the MEW scaffold. Here, we reported a method to solve this dilemma by electrospinning a gelatin methacrylate (GelMA) hydrogel fibers membrane (HFM) on the MEW scaffold. This composite scaffold can own the controlled structures and porosity and excellent cell seeding performance. We systematically investigate the fabrication, morphology, and biocompatibility of composite scaffolds. The implanting of human umbilical vein endothelial cells(HUVES) showed excellent adhesion and biocompatibility on the composite scaffold. Moreover, the cells migrated gradually into the MEW scaffold along the GelMA HFM to form the cell sheet. We hold the opinion that the composite scaffolds have potential applications in the field of tissue engineering repair.
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