Efficient Pd-Catalyzed Hydrodehalogenation of o-Haloanilides in Water

In the present work, we have developed a practical methodology for the hydrodehalogenation of o-haloanilides using PdCl2 at 100 °C under mild conditions in water. The catalytic system could selectively dehalogenate both aryl chloride and aryl bromide and exhibit a broad functional group tolerance.