神经科学
人脑
类有机物
前脑
诱导多能干细胞
大脑发育
生物
神经干细胞
胚胎干细胞
干细胞
中枢神经系统
细胞生物学
生物化学
基因
作者
Augustin Chen,Zhenming Guo,Li‐Pao Fang,Shan Bian
标识
DOI:10.3389/fncel.2020.00133
摘要
Human brain organoids cultured from human pluripotent stem cells provide a promising platform to recapitulate histological features of the human brain and model neural disorders. However, unlike animal models, brain organoids lack a reproducible topographic organization, which limits their application in modeling intricate biology, such as the interaction between different brain regions. To overcome these drawbacks, brain organoids have been pre-patterned into specific brain regions and fused to form an assembloid that represents reproducible models recapitulating more complex biological processes of human brain development and neurological diseases. This approach has been applied to model interneuron migration, neuronal projections, tumor invasion, oligodendrogenesis, forebrain axis establishment, and brain vascularization. In this review article, we will summarize the usage of this technology to understand the fundamental biology underpinning human brain development and disorders.
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