Penehyclidine Hydrochloride Premedication Is Not Associated with Increased Incidence of Post-Operative Cognitive Dysfunction or Delirium:A Systemic Review and Meta-Analysis

医学 麻醉 优势比 谵妄 随机对照试验 荟萃分析 统计显著性 置信区间 术后认知功能障碍 安慰剂 入射(几何) 内科学 认知 重症监护医学 精神科 物理 光学 替代医学 病理
作者
Yun-tai Yao,Ying Hua,Nengxin Fang,Yongbao Zhang,Xin Yuan
出处
期刊:Chinese Medical Sciences Journal [Elsevier BV]
卷期号:35 (2): 121-134 被引量:4
标识
DOI:10.24920/003630
摘要

Objective Post-operative cognitive dysfunction (POCD) and post-operative delirium (POD) are two common post-operative cerebral complications. The current meta-analysis was to systematically review the effects of penehyclidine hydrochloride (PHC) on POCD and POD in surgical patients.Methods Electronic databases were searched to identify all randomized controlled trials comparing PHC with atropine/scopolamine/placebo on POCD and POD in surgical patients. Primary outcomes of interest included the incidences of POCD and POD; the secondary outcomes of interest included peri-operative mini-mental state examination (MMSE) scores. Two authors independently extracted peri-operative data, including patients' baseline characteristics, surgical variables, and outcome data. For dichotomous data (POCD and POD occurrence), treatment effects were calculated as odds ratio (OR) and 95% confidential interval (CI). Each outcome was tested for heterogeneity, and randomized-effects or fixed-effects model was used in the presence or absence of significant heterogeneity. For continuous variables (MMSE scores), treatment effects were calculated as weighted mean difference (WMD) and 95% CI. Statistical significance was defined as P<0.05.Results Our search yielded 33 studies including 4017 patients. Meta-analysis showed that, the incidence of POCD in PHC group was comparable to that in saline group (OR=0.97; 95% CI: 0.58-1.64; P=0.92), scopolamine group (OR=0.78; 95% CI: 0.48-1.27; P=0.32) and atropine group (OR=1.20; 95% CI: 0.86-1.67; P=0.29). The incidence of POD in PHC group was comparable to that in saline group (OR=1.53; 95% CI: 0.81-2.90; P=0.19) and scopolamine group (OR=0.53; 95% CI: 0.06-4.56; P=0.56), but higher than that in atropine group (OR=4.49; 95% CI: 1.34-15.01; P=0.01).Conclusions PHC premedication was not associated with increased incidences of POCD or POD as compared to either scopolamine or placebo.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
嘉1612完成签到,获得积分10
刚刚
刚刚
科研通AI2S应助angrymax采纳,获得10
刚刚
落尘发布了新的文献求助10
1秒前
学不懂数学应助小王采纳,获得10
1秒前
量子星尘发布了新的文献求助10
1秒前
ROOKIE完成签到,获得积分10
2秒前
2秒前
阿胡发布了新的文献求助10
3秒前
3秒前
SYLH应助wodetaiyangLLL采纳,获得10
4秒前
loey完成签到,获得积分10
4秒前
等待的音响完成签到,获得积分10
4秒前
4秒前
孙非完成签到,获得积分10
4秒前
江小鱼在查文献完成签到,获得积分10
5秒前
静xixi完成签到,获得积分20
6秒前
就是躺完成签到 ,获得积分10
7秒前
7秒前
xcc完成签到,获得积分10
8秒前
目眩完成签到,获得积分10
8秒前
等待的花卷完成签到 ,获得积分10
9秒前
莫言发布了新的文献求助10
10秒前
潇潇完成签到,获得积分10
10秒前
YY-Bubble完成签到,获得积分10
10秒前
lulu8809发布了新的文献求助20
10秒前
lJH发布了新的文献求助10
11秒前
莫言完成签到,获得积分10
14秒前
冷艳的道天完成签到 ,获得积分10
16秒前
Angela完成签到,获得积分10
19秒前
lJH完成签到,获得积分10
19秒前
Popeye完成签到,获得积分10
21秒前
pluto应助李李采纳,获得10
24秒前
研友_7ZebY8完成签到,获得积分10
25秒前
合适怡完成签到,获得积分10
25秒前
开朗的慕儿完成签到,获得积分10
25秒前
26秒前
27秒前
我要发财发布了新的文献求助10
28秒前
David完成签到 ,获得积分10
29秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029