医学
微生物群
支气管扩张
囊性纤维化
肺
肺炎
慢性阻塞性肺病
哮喘
免疫学
阻塞性肺病
呼吸道
病理
呼吸系统
生物信息学
内科学
生物
作者
Manoj J. Mammen,Frank A. Scannapieco,Sanjay Sethi
摘要
Abstract The proximity and continuity of the oral cavity and the lower respiratory tract allows the oropharyngeal microbiome to be a major determinant of the lung microbiome. In addition, host‐pathogen interactions related to the oropharyngeal microbiome or its metabolites could propagate systemic inflammation or modulate host defense mechanisms that could affect other organs, including the lung. There is increasing appreciation of the pathophysiologic significance of the lung microbiome, not only in the classical infection‐related diseases, pneumonia, bronchiectasis, and cystic fibrosis, but also in chronic noninfectious lung diseases, such as chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis. In this review, we will explore the relationship of the oral microbiome with lung diseases, such as pneumonia, chronic obstructive pulmonary disease, asthma, and cystic fibrosis.
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