免疫系统
癌症研究
表达式(计算机科学)
计算生物学
生物
医学
计算机科学
免疫学
程序设计语言
作者
Shuming Chen,George A. Crabill,Theresa S. Pritchard,Tracee L. McMiller,Ping Wei,Drew M. Pardoll,Fan Pan,Suzanne L. Topalian
标识
DOI:10.1186/s40425-019-0770-2
摘要
The PD-1/PD-L1 checkpoint is a central mediator of immunosuppression in the tumor immune microenvironment (TME) and is primarily associated with IFN-g signaling. To characterize other factors regulating PD-L1 expression on tumor and/or immune cells, we investigated TME-resident cytokines and the role of transcription factors in constitutive and cytokine-induced PD-L1 expression.
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