Oxytocin modulates neural processing of mitral/tufted cells in the olfactory bulb

嗅球 催产素 神经科学 嗅觉系统 抑制性突触后电位 生物 人口 中枢神经系统 医学 环境卫生
作者
Chongling Sun,Zhaoyang Yin,Ben‐Zheng Li,Han Du,Tang Ke-ke,Penglai Liu,Sio Hang Pun,Tim C. Lei,Anan Li
出处
期刊:Acta Physiologica [Wiley]
卷期号:231 (4) 被引量:13
标识
DOI:10.1111/apha.13626
摘要

Abstract Aim Oxytocin plays an important role in social recognition in rodents, which is mediated predominantly by the olfactory system. Although oxytocin modulates neural activity in the olfactory bulb, the underlying mechanism is largely unknown. Here, we studied how direct infusion of oxytocin into the olfactory bulb affect social interactions in mice and modulate the neural activity of mitral/tufted cells in the olfactory bulb. Methods A three‐chamber social interaction test was used in the behavioural test. For in vivo studies, single unit recordings, local field potential recordings and fibre photometry recordings were used to record the neural activity of olfactory bulb. For in vitro studies, we performed patch clamp recordings in the slice of the olfactory bulb. Results Behaviourally, direct oxytocin infusion in olfactory bulb increased performance in a social interaction task. Moreover, odour‐evoked responses of mitral/tufted cells and neural discrimination of odours were both enhanced by oxytocin, whereas the spontaneous firing rate of mitral/tufted cells was reduced. At the neural network level, oxytocin decreased the amplitude of odour‐evoked high gamma responses. At the cell population level, oxytocin decreased odour‐evoked calcium responses (reflecting neural activity) specifically in granule cells. Moreover, in vitro slice recordings revealed that the inhibitory effect of oxytocin on mitral cell activity is mediated mainly by modulation of ATP‐sensitive potassium channels and involves the oxytocin receptor–Gq–PLC–IP 3 signalling pathway. Conclusion Oxytocin modulates social interaction, likely by increasing the signal‐to‐noise ratio of odour responses in mitral cells which is partly through ATP‐sensitive potassium channel.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Balance Man发布了新的文献求助10
1秒前
迅速从霜完成签到,获得积分10
2秒前
大强完成签到,获得积分10
2秒前
开朗白玉完成签到,获得积分10
6秒前
能用就行发布了新的文献求助10
6秒前
6秒前
修仙应助深情冷雪采纳,获得10
9秒前
10秒前
完美世界应助cky采纳,获得10
10秒前
11秒前
可爱的函函应助牛人采纳,获得10
14秒前
15秒前
瞒总完成签到,获得积分10
16秒前
yangyunheng完成签到,获得积分10
17秒前
一颗煤炭完成签到 ,获得积分10
18秒前
淡淡的以柳完成签到,获得积分10
18秒前
aiyangyang完成签到 ,获得积分10
20秒前
21秒前
深情安青应助甜崽采纳,获得10
21秒前
22秒前
22秒前
诚心钢笔完成签到 ,获得积分10
23秒前
猪猪发布了新的文献求助10
28秒前
李爱国应助苗小七采纳,获得10
28秒前
雨声完成签到,获得积分10
30秒前
紫羽完成签到,获得积分20
31秒前
33秒前
36秒前
猪猪完成签到,获得积分10
37秒前
40秒前
脑洞疼应助summer1128采纳,获得10
40秒前
lq67gg完成签到 ,获得积分10
41秒前
劲秉应助HM采纳,获得10
42秒前
学习要认真喽完成签到,获得积分10
42秒前
七七七发布了新的文献求助10
43秒前
苗小七发布了新的文献求助10
43秒前
44秒前
wangxc完成签到 ,获得积分10
45秒前
vetY完成签到,获得积分10
46秒前
虚心丹秋发布了新的文献求助10
48秒前
高分求助中
Earth System Geophysics 1000
Co-opetition under Endogenous Bargaining Power 666
Medicina di laboratorio. Logica e patologia clinica 600
Handbook of Marine Craft Hydrodynamics and Motion Control, 2nd Edition 500
Sarcolestes leedsi Lydekker, an ankylosaurian dinosaur from the Middle Jurassic of England 500
《关于整治突出dupin问题的实施意见》(厅字〔2019〕52号) 500
Language injustice and social equity in EMI policies in China 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3212348
求助须知:如何正确求助?哪些是违规求助? 2861200
关于积分的说明 8127627
捐赠科研通 2527168
什么是DOI,文献DOI怎么找? 1360782
科研通“疑难数据库(出版商)”最低求助积分说明 643322
邀请新用户注册赠送积分活动 615664