Subgingival Microbiota during Healthy Pregnancy and Pregnancy Gingivitis

牙龈炎 怀孕 微生物群 口腔微生物群 生理学 医学 产科 生物 牙科 生物信息学 遗传学
作者
Preethi Balan,Bernd W. Brandt,Yap Seng Chong,Wim Crielaard,Mun Loke Wong,Violeta Lopez,Huiguang He,Chaminda Jayampath Seneviratne
出处
期刊:JDR clinical and translational research [SAGE]
卷期号:6 (3): 343-351 被引量:12
标识
DOI:10.1177/2380084420948779
摘要

Introduction: Previous studies have largely explored the microbial composition and pathogenesis of pregnancy gingivitis. However, the patterns of microbial colonization during pregnancy in the absence of pregnancy gingivitis have rarely been studied. Characterization of the oral microbiome in pregnant women with healthy gingiva is an important initial step in understanding the role of the microbiome in progression to pregnancy gingivitis. Objectives: In this study, we compared the oral microbiome of pregnant women without gingivitis (healthy pregnancy) with pregnant women having gingivitis and nonpregnant healthy women to understand how pregnancy modifies the oral microbiome and induces progression to pregnancy gingivitis. Methods: Subgingival plaque samples were collected from Chinese pregnant women with gingivitis ( n = 10), healthy pregnant women ( n = 10), and nonpregnant healthy women ( n = 10). The Illumina MiSeq platform was used to perform 16S rRNA gene sequencing targeting the V4 region. Results: The alpha and beta diversity was significantly different between pregnant and nonpregnant women, but minimal differences were observed between pregnant women with and without gingivitis. Interestingly, the oral bacterial community showed higher abundance of pathogenic taxa during healthy pregnancy as compared with nonpregnant women despite similar gingival and plaque index scores. However, when compared with overt pregnancy gingivitis, pathogenic taxa were less abundant during healthy pregnancy. PICRUSt analysis (phylogenetic investigation of communities by reconstruction of unobserved states) also suggested no difference in the functional capabilities of the microbiome during pregnancy, irrespective of gingival disease status. However, metabolic pathways related to amino acid metabolism were significantly increased in healthy pregnant women as compared with nonpregnant women. Conclusion: The presence of pathogenic taxa in healthy pregnancy and pregnancy gingivitis suggests that bacteria may be necessary for initiating disease development but progression to gingivitis may be influenced by the host environmental factors. More efforts are required to plan interventions aimed at sustaining health before the appearance of overt gingivitis. Knowledge Transfer Statement: The results of this study draw attention to the importance of oral health maintenance during pregnancy, as women without any prenatal oral conditions are predisposed to the risk of developing pregnancy gingivitis. Hence, it is important to incorporate comprehensive assessment of oral health in the prenatal health care schedules. Pregnant woman should be screened for oral risks, counseled on proper oral hygiene and expected oral changes, and referred for dental treatment, when necessary.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Likj完成签到,获得积分10
刚刚
情怀应助pK采纳,获得10
1秒前
1秒前
1秒前
2秒前
3秒前
嘿哈发布了新的文献求助10
3秒前
3秒前
乐乐应助动听静槐采纳,获得10
4秒前
LF发布了新的文献求助10
4秒前
鲜于枫发布了新的文献求助30
4秒前
4秒前
哔哔鱼完成签到,获得积分10
4秒前
llll完成签到,获得积分10
4秒前
所所应助西西弗斯采纳,获得10
5秒前
5秒前
5秒前
5秒前
6秒前
花海发布了新的文献求助10
6秒前
7秒前
悲伤水凝胶完成签到,获得积分10
7秒前
小二郎应助pK采纳,获得10
8秒前
烟花应助果粒橙980采纳,获得10
8秒前
汉堡包应助孤岛采纳,获得10
8秒前
六七七发布了新的文献求助10
9秒前
xlj发布了新的文献求助10
9秒前
9秒前
科研小举人完成签到,获得积分10
9秒前
枫叶发布了新的文献求助10
10秒前
koriel发布了新的文献求助10
10秒前
鲜于枫完成签到,获得积分10
11秒前
看你个完成签到,获得积分10
11秒前
何处芳歇完成签到,获得积分10
11秒前
11秒前
CipherSage应助小石头采纳,获得10
12秒前
hulala完成签到,获得积分10
12秒前
艾客科研发布了新的文献求助10
12秒前
可问春风发布了新的文献求助10
14秒前
飞翔的葡萄籽完成签到,获得积分10
14秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3546888
求助须知:如何正确求助?哪些是违规求助? 3123917
关于积分的说明 9357332
捐赠科研通 2822504
什么是DOI,文献DOI怎么找? 1551513
邀请新用户注册赠送积分活动 723546
科研通“疑难数据库(出版商)”最低求助积分说明 713791