甲壳素
材料科学
自愈水凝胶
纳米颗粒
纳米技术
壳聚糖
多孔性
自愈
透射电子显微镜
化学工程
超临界干燥
气凝胶
复合材料
高分子化学
病理
工程类
医学
替代医学
作者
Xiaojia Guo,Didi Xu,Yanan Zhao,Huimin Gao,Xiaowen Shi,Jie Cai,Hongbing Deng,Yun Chen,Yumin Du
标识
DOI:10.1021/acsami.9b13063
摘要
The construction of polymeric nanocomponents into a hierarchical structure poses great importance for subsequent biomedical applications. Herein, we report for the first time the electroassembly of chitin nanoparticles (14 nm ± 3 nm from transmission electron microscopy) to construct thick and freestanding hydrogels, which can be further dried to obtain high porous and tough aerogels for wound healing. The electroassembly is a simple, straightforward, and controllable process, which crucially depends on the pH of the chitin nanoparticle suspension and the degree of deacetylation of chitin. Interestingly, the electroassembly of chitin nanoparticles is completely reversible, suggesting the physical assembly feature of the freestanding hydrogel. By using supercritical CO2 drying and freeze-drying, chitin aerogels and cryogels can be facilely obtained. Because of the intriguing features (i.e., large surface area, interconnected porous structure, and enhanced hydrophilicity), chitin aerogels demonstrate adorable performance to accelerate the healing of wounds.
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