16202 Effect of high-mobility group box 1 on keratinocyte and fibroblast and its involvement in the development of psoriasis

Background: Psoriasis is a chronic immune-mediated inflammatory skin disease, in which keratinocyte and fibroblast play an important role. High-mobility group protein B1 (HMGB1) is a nuclear protein that routinely participates in the maintenance of genomic stability and the regulation of gene transcription. HMGB1 is also a physiological activator of immune responses that can be released from keratinocyte and fibroblast nuclei in psoriatic lesions. Although it is implicated in the pathogenesis of autoimmune diseases and cutaneous disorders, the precise role of HMGB1 in psoriasis has yet to be studied.