Study Design. A cross-sectional study. Objective. Th aim of this study was to translate and cross-culturally adapt Copenhagen Neck Function Disability Scale into a Simplified Chinese version (CNFDS-C), and evaluate the reliability and validity of CNFDS-C in patients with nonspecific chronic neck pain. Summary of Background Data. The CNFDS is a reliable and valid evaluation instrument for chronic neck pain. However, Simplified Chinese version of CNFDS hasn’t been validated. Methods. A total of 150 participants were included in this study. Internal consistency was estimated according to Cronbach alpha. Test–retest reliability was assessed by intra-class correlation coefficient (ICC). Construct validity was analyzed by correlations between CNFDS-C and the Neck Disability Index (NDI), Visual Analogue Scale (VAS) as well as the short form (36) health survey (SF-36). Results. The original version of the CNFDS was cross-culturally adapted and translated into Simplified Chinese. CNFDS-C was indicated to have excellent reliability (Cronbach alpha = 0.810, ICC = 0.927). Moderate to substantial correlations between CNFDS-C and NDI ( r = 0.642, P < 0.001), VAS ( r = 0.581, P < 0.001), as well as Physical Function ( r = −0.583, P < .001), Role Physical ( r = −0.478, P < 0.001), Bodily Pain ( r = −0.610, P < 0.001), and General Health ( r = −0.439, P < 0.001) subscales of SF-36 were observed. Conclusion. CNFDS-C was demonstrated to have acceptable reliability and validity in patients with nonspecific chronic neck pain, which could be recommended for patients in Chinese mainland. Level of Evidence: 3