成纤维细胞活化蛋白
翻译(生物学)
化学
计算生物学
谷氨酸羧肽酶Ⅱ
小分子
肽
分子成像
前列腺癌
医学
癌症
癌症研究
生物化学
生物
内科学
体内
生物技术
信使核糖核酸
基因
作者
Guillermina Ferro‐Flores,Blanca Ocampo‐García,Myrna Luna‐Gutiérrez,Clara Santos‐Cuevas,Nallely Jiménez‐Mancilla,Erika Azorín‐Vega,Laura Meléndez‐Alafort
标识
DOI:10.2174/0929867327666191223121211
摘要
Protein interactions are the basis for the biological functioning of human beings. However, many of these interactions are also responsible for diseases, including cancer. Synthetic inhibitors of protein interactions based on small molecules are widely investigated in medicinal chemistry. The development of radiolabeled protein-inhibitor peptides for molecular imaging and targeted therapy with quickstep towards clinical translation is an interesting and active research field in the radiopharmaceutical sciences. In this article, recent achievements concerning the design, translational research and theranostic applications of structurally-modified small radiopeptides, such as prostate-specific membrane antigen (PSMA) inhibitors, fibroblast activation protein (FAP) inhibitors and antagonists of chemokine-4 receptor ligands (CXCR-4-L), with high affinity for cancer-associated target proteins, are reviewed and discussed.
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