软骨发生
软骨膜
软骨
软骨细胞
细胞生物学
软骨内骨化
作者
Tord Skoog,Lennart Ohlsén,Stephen A. Sohn
出处
期刊:Chirurgia plastica
[Springer Nature]
日期:1975-06-01
卷期号:3 (2): 91-103
被引量:41
摘要
The chondrogenic capacity of the perichondrium was first demonstrated by Skoog, Ohlsen and Sohn in 1972. To further elucidate this finding large series of experiments have been carried out in 2-month-old rabbits. In surgically created defects in ear cartilage, 10×15 mm and 18×18 mm, a proliferation of new cartilage was seen in all cases where a perichondrial flap had been used to bridge the defect. No growth of cartilage was found in the control groups. The formation of new cartilage originated from the deep surface of the perichondrial flap, i.e. from cell layers adjacent to the cartilage before separation of the flap. The effect of hematoma as a matrix for this growth was evident. Some experiments were devised to confirm that the perichondrium is the source of the formation of new cartilage, excluding the possibility of the cartilage edges participating in the chondrogenesis.
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