神经化学
抗抑郁药
多巴胺
神经递质
单胺类神经递质
去甲肾上腺素
萧条(经济学)
精神科
心理学
内源性抑郁症
重性抑郁障碍
神经科学
内科学
医学
血清素
中枢神经系统
焦虑
受体
认知
心情
经济
宏观经济学
出处
期刊:PubMed
日期:2008-01-01
卷期号:69 Suppl E1: 4-7
被引量:393
摘要
A relationship appears to exist between the 3 main monoamine neurotransmitters in the brain (i.e., dopamine, norepinephrine, and serotonin) and specific symptoms of major depressive disorder. Specific symptoms are associated with the increase or decrease of specific neurotransmitters, which suggests that specific symptoms of depression could be assigned to specific neurochemical mechanisms, and subsequently specific antidepressant drugs could target symptom-specific neurotransmitters. Research on electroconvulsive therapy has supported a correlation between neurotransmitters and depression symptoms. A 2-dimensional model of neurotransmitter functions is discussed that describes depression as a mixture of 2 separate components--negative affect and the loss of positive affect--that can be considered in relation to the 3 amine neurotransmitters. Owing to the different methods of action of available antidepressant agents and the depression symptoms thought to be associated with dopamine, serotonin, and norepinephrine, current treatments can be targeted toward patients' specific symptoms.
科研通智能强力驱动
Strongly Powered by AbleSci AI