细胞周期
细胞周期检查点
细胞生物学
细胞周期蛋白
DNA损伤
生物
乙酰化
细胞
细胞生长
体内
DNA修复
细胞凋亡
遗传学
DNA
基因
作者
Sophie North,Pierre Hainaut
出处
期刊:PubMed
日期:2000-04-01
卷期号:48 (3): 255-70
被引量:15
摘要
The p53 protein plays diverse, complementary roles in the regulation of cell proliferation, genetic integrity and survival after exposure to various forms of genotoxic and non-genotoxic stresses. While there is considerable in vivo evidence that induction of apoptosis in response to DNA damage is an important biological response mediated by p53, the physiological role of p53 in the control of the cell cycle is still poorly understood. In this review, we first discuss evidence showing that p53 expression, protein level and activity are regulated in a cell-cycle dependent manner (by transcriptional control, control of protein stability, and changes in phosphorylation, acetylation and protein conformation). We then summarize the data available on the direct or indirect involvement of p53 in the control of cell-cycle progression in G1, S, G2 and M phases. Based on recent in vitro and in vivo data, we suggest that permanent cell-cycle arrest may represent a response to stress in cells with limited proliferative potential, which allows both genetic and tissular integrity to be preserved. We also discuss the way in which cell-cycle regulation may contribute to control p53 protein levels and activity during the normal cell cycle.
科研通智能强力驱动
Strongly Powered by AbleSci AI