化学
部分
抗原
磷脂酰胆碱
两亲性
生物化学
膜
立体化学
生物
磷脂
有机化学
共聚物
聚合物
遗传学
作者
Karin Lövgren,Brør Morein
标识
DOI:10.1111/j.1470-8744.1988.tb00012.x
摘要
The iscom–immunostimulating complex–is a highly immunogenic formulation of microbial membrane antigens. The biochemically analyzed components of the iscom are the protein and the glycoside Quil A. Continued analysis of the iscom showed that the protein moiety–the antigen–does not contribute to the iscom as a construct. Instead, cholesterol and Quil A are the essential structural components assembled together into a typical cage‐like structure. A more “fluid” lipid, such as phosphatidylcholine, is needed to facilitate the incorporation of amphipathic poly‐ or oligopeptides into the iscom matrix.
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