纳米技术
等离子体子
生物传感器
微电子
材料科学
纳米光子学
微流控
背景(考古学)
纳米棒
实验室晶片
光电子学
生物
古生物学
作者
Ozlem Yavas,Mikael Svedendahl,Paulina Dobosz,Vanesa Sanz,Romain Quidant
出处
期刊:Nano Letters
[American Chemical Society]
日期:2017-06-16
卷期号:17 (7): 4421-4426
被引量:174
标识
DOI:10.1021/acs.nanolett.7b01518
摘要
Nanophotonics has become a key enabling technology in biomedicine with great promises in early diagnosis and less invasive therapies. In this context, the unique capability of plasmonic noble metal nanoparticles to concentrate light on the nanometer scale has widely contributed to biosensing and enhanced spectroscopy. Recently, high-refractive index dielectric nanostructures featuring low loss resonances have been proposed as a promising alternative to nanoplasmonics, potentially offering better sensing performances along with full compatibility with the microelectronics industry. In this letter we report the first demonstration of biosensing with silicon nanoresonators integrated in state-of-the-art microfluidics. Our lab-on-a-chip platform enables detecting Prostate Specific Antigen (PSA) cancer marker in human serum with a sensitivity that meets clinical needs. These performances are directly compared with its plasmonic counterpart based on gold nanorods. Our work opens new opportunities in the development of future point-of-care devices toward a more personalized healthcare.
科研通智能强力驱动
Strongly Powered by AbleSci AI