化学
邻接
催化作用
烯烃纤维
区域选择性
碳阳离子
亲核细胞
氟化物
分子间力
有机化学
组合化学
分子
无机化学
作者
Dengfu Lu,Cheng‐Liang Zhu,Jeffrey D. Sears,Hao Xu
摘要
We herein report a new catalytic method for intermolecular olefin aminofluorination using earth-abundant iron catalysts and nucleophilic fluoride ion. This method tolerates a broad range of unfunctionalized olefins, especially nonstyrenyl olefins that are incompatible with existing olefin aminofluorination methods. This new iron-catalyzed process directly converts readily available olefins to internal vicinal fluoro carbamates with high regioselectivity (N vs F), many of which are difficult to prepare using known methods. Preliminary mechanistic studies demonstrate that it is possible to exert asymmetric induction using chiral iron catalysts and that both an iron-nitrenoid and carbocation species may be reactive intermediates.
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