鸟氨酸
尿素循环
鸟氨酸脱羧酶抗体
生物化学
精氨酸酶
鸟氨酸转氨酶
瓜氨酸
多胺
氨基酸
代谢途径
化学
鸟氨酸脱羧酶
酶
生物
细胞生物学
精氨酸
作者
Muthukumaran Sivashanmugam,J. Jaidev,Umashankar Vetrivel,K N Sulochana
标识
DOI:10.1016/j.biopha.2016.12.024
摘要
Ornithine is a non-essential amino acid produced as an intermediate molecule in urea cycle. It is a key substrate for the synthesis of proline, polyamines and citrulline. Ornithine also plays an important role in the regulation of several metabolic processes leading to diseases like hyperorithinemia, hyperammonemia, gyrate atrophy and cancer in humans. However, the mechanism of action behind the multi-faceted roles of ornithine is yet to be unraveled completely. Several types of cancers are also characterized by excessive polyamine synthesis from ornithine by different rate limiting enzymes. Hence, in this review we aim to provide extensive insights on potential roles of ornithine in many of the disease related cellular processes and also on the structural features of ornithine interacting proteins, enabling development of therapeutic modalities.
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