Clinicopathological features, treatment modalities, and prognosis of esophageal neuroendocrine carcinoma: A single‐center retrospective study

医学 神经内分泌癌 内科学 回顾性队列研究 治疗方式 模式 肿瘤科 单中心 中心(范畴论) 普通外科 放射科 结晶学 社会学 化学 社会科学
作者
Y Zhang,J T Liao,Ying Lin,Chang Liu,Zhen Wu,Bo Yu,Si Sun,Hui Yu,Xiao Hua Hui,Xiang Hua Wu,Xin Zhao,Hui Jie Wang,Qiang Zheng,Yuan Li,Zhi Hu,Jia Lei Wang
出处
期刊:Journal of Digestive Diseases [Wiley]
卷期号:24 (8-9): 472-479 被引量:2
标识
DOI:10.1111/1751-2980.13219
摘要

Esophageal neuroendocrine carcinoma (ENEC) is a rare cancer that is highly malignant and related to a poor prognosis. In this retrospective study we aimed to elucidate the clinical characteristics, diagnosis and management of patients with ENEC and to evaluate the potential prognostic factors.Altogether 82 patients diagnosed with ENEC between January 2009 and December 2020 at the Fudan University Shanghai Cancer Center were retrospectively enrolled. Patients' survival was analyzed using the Kaplan-Meier and log-rank methods. Univariate and multivariate analyses and a Cox regression model were used to identify the prognostic factors.The median overall survival (mOS) was 13 months in all patients. Multivariate analysis revealed that advanced tumor stage (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.07-6.66, P = 0.0353), liver (HR 3.36, 95% CI 1.53-7.41, P = 0.0026) and lung metastasis (HR 3.37, 95% CI 1.20-9.51, P = 0.0214) were associated with a poor prognosis. While positive chromogranin A (CgA) expression was related to a favorable outcome (HR 0.21, 95% CI 0.09-0.49, P < 0.001). Also, patients had adjustment of chemotherapy (dose reduction or less than three cycles) were prone to a worse prognosis compared with those did not (HR 4.36, 95% CI 2.10-9.08, P < 0.001).In patients with ENEC, advanced cancer stage, adjustment of chemotherapy, liver and lung metastasis were associated with a poor survival, while CgA expression was related to a favorable prognosis.
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