自愈水凝胶
壳聚糖
席夫碱
香豆素
氢键
化学
控制释放
肿胀 的
核化学
自愈
高分子化学
化学工程
生物物理学
材料科学
分子
有机化学
纳米技术
复合材料
医学
替代医学
病理
工程类
生物
作者
Haolei Shi,Dongxu Ma,Di Wu,Qiu Xiao,Shuai Yang,Yingying Wang,Lei Xiao,Xuewu Ji,Zhang We,Shuaiyuan Han,Pengfei Huo,Jidong Dong,Xianzhi Kong,Guan Xue,Dawei Zhang
标识
DOI:10.1016/j.ijbiomac.2023.128122
摘要
Smart hydrogels have shown great potential applications in disease treatment due to their controlled and local drug-release ability. Herein, a smart hydrogel with pH-responsive, injectable, and self-healing properties for controlled release of taxifolin (TFL) was prepared by freezing-thawing and photo-crosslinking methods. The crosslinking network of hydrogels (CS-CA hydrogels) was constructed by the hydrogen bonds, Schiff base bonds, and cyclobutane rings using chitosan (CS) and coumarin (CA) as raw materials. The CS-CA hydrogel demonstrated a compressive strength of 1.04 MPa, a self-healing efficiency of 99.9 %, and could maintain structural and functional integrity after injection. In addition, the drug release rate and shape of the CS-CA hydrogels were tunable due to its pH sensitivity. The TFL cumulative release reached 60 % within 12 h at pH = 4, and after equilibration, the cumulative release of TFL at pH = 4 (80 %) was significantly higher than at pH = 9.2 (50 %). The CCK8 experiment showed that the resulting hydrogel had no cytotoxicity. Meanwhile, subcutaneous implantation experiments in mice showed that the CS-CA hydrogels had favorable biodegradability and compatibility.
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