生物
普雷沃菌属
阴道菌群
乳酸菌
维管菌
阴道
微生物学
微生物群
消化链球菌
链球菌
生理学
免疫学
细菌性阴道病
细菌
厌氧菌
生物信息学
遗传学
作者
Qiliang Yang,Yinan Wang,Chonghun Han,Qian Zhou,Liping Zeng,Shuai Cheng Li,Hui Du,Weixia Wei,Wei Zhang,Wenkui Dai,Ruifang Wu
标识
DOI:10.1016/j.micpath.2023.106309
摘要
The etiology remains to be understood for endometriosis (EMS) which affected health negatively for 10% of reproductive-age women globally. Emerging studies found the associations of EMS with genital microbiota dysbiosis. However, the role of vaginal and cervical microbiota is not fully understood for Chinese women. This study recruited forty Chinese women (21 healthy women and 19 EMS patients) to analyze vaginal and cervical microbiota using 16S rRNA amplicon sequencing method. For both sites, there were no significant differences for distribution of microbial samples between control and EMS group, which was concordant with dominated Lactobacillus in both groups. In contrast, we observed accumulation of several low-abundance genera in vaginal and cervical microbiota of EMS patients, such as Fannyhessea, Prevotella, Streptococcus, Bifidobacterium, Veillonella, Megasphaera and Sneathia. Random forest analysis found that translocation of these genera had the significant importance in differentiating EMS patients from controls. In addition, cervix/vagina ratio of these genera also associated with EMS severity. And these genera had notable associations with ascending infection-related functional pathways, including flagellar assembly, bacterial motility proteins, bacterial toxins and epithelial cell signaling in Helicobacter pylori infection. These findings suggest that translocation of specific genera between vaginal and cervical sites play a role in EMS.
科研通智能强力驱动
Strongly Powered by AbleSci AI