Selective Inhibition of NaV1.8 with VX-548 for Acute Pain
医学
麻醉
急性疼痛
药理学
内科学
作者
J. W. Jones,Darin Correll,Sandra Lechner,Ina Jazić,Xiaopeng Miao,David Shaw,C Simard,Jeremiah D. Osteen,Brian Hare,Alina Beaton,Todd Bertoch,Asokumar Buvanendran,Ashraf S. Habib,Lois J. Pizzi,Richard Pollak,Scott G. Weiner,Carmen Bozic,Paul A. Negulescu,Paul F. White
The NaV1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548, an oral, highly selective inhibitor of NaV1.8, on control of acute pain is being studied.
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一一
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