Rapid and sensitive point-of-need aflatoxin B1 testing in feedstuffs using a smartphone-powered mobile microfluidic lab-on-fiber device

软件可移植性 微流控 光纤 材料科学 纳米技术 计算机科学 电信 程序设计语言
作者
Yuxin Zhuo,Wenjuan Xu,Yuan Chen,Feng Long
出处
期刊:Journal of Hazardous Materials [Elsevier BV]
卷期号:460: 132406-132406 被引量:7
标识
DOI:10.1016/j.jhazmat.2023.132406
摘要

Rapid, high-frequency, and accurate identification of aflatoxin B1 (AFB1) is crucial for ensuring food safety and reducing population mortality. Herein, we constructed Smartphone powered Mobile mIcrofluidic Lab-on-fiber dEvice (SMILE) comprising a compact optical system, fiber nano-bioprobe-embedded microfluidic-chip system, mini-photodetector, and software application to facilitate the rapid and sensitive point-of-need quantitative testing for AFB1. The elegant optical design of SMILE significantly improves light transmission efficiency, detection sensitivity, and portability by integrating a compacted all-fiber optical structure with a fiber nano-bioprobe-embedded microfluidic chip. Furthermore, the nanopore layer of the fiber nano-bioprobe improves detection sensitivity by increasing the biorecognition molecule number and enhancing the interaction between the evanescent field and dye. Through an indirect competitive immunoassay mechanism, SMILE achieves sensitive quantitative detection of AFB1 with a detection limit of 0.08 µg/L. Herein, SMILE was validated using several feedstuff samples tested with a simple aqueous extraction protocol, demonstrating good correlation with high-performance liquid chromatography for AFB1-contaminated feedstuffs. The immunoassay process is completed within 12 min, boasting high sensitivity, specificity, reusability, and reproducibility. Owing to its sensitivity, portability, flexibility, plug-and-play, and smartphone integration, SMILE is highly scalable for rapid and high-frequency point-of-need testing for AFB1 and other trace contaminants.
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