生长素
癌变
脂联素
胰腺
炎症
医学
瘦素
肥胖
胰腺癌
脂肪因子
胰岛素抵抗
脂肪组织
肿瘤微环境
免疫系统
癌症研究
内科学
腺癌
内分泌学
肿瘤科
激素
癌症
免疫学
作者
Mundla Srilatha,Rama Rao Malla,Megha Priya Adem,Jeremy B. Foote,Ganji Purnachandra Nagaraju
标识
DOI:10.1016/j.semcancer.2023.11.002
摘要
Obesity is a prominent health issue worldwide and directly impacts pancreatic health, with obese individuals exhibiting a significant risk for increasing pancreatic ductal adenocarcinoma (PDAC). Several factors potentially explain the increased risk for the development of PDAC, including obesity-induced chronic inflammation within and outside of the pancreas, development of insulin resistance and metabolic dysfunction, promotion of immune suppression within the pancreas during inflammation, pre- and malignant stages, variations in hormones levels (adiponectin, ghrelin, and leptin) produced from the adipose tissue, and acquisition of somatic mutations in tumor once- and suppressor proteins critical for pancreatic tumorigenesis. In this manuscript, we will explore the broad impact of these obesity-induced risk factors on the development and progression of PDAC, focusing on changes within the tumor microenvironment (TME) as they pertain to prevention, current therapeutic strategies, and future directions for targeting obesity management as they relate to the prevention of pancreatic tumorigenesis.
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