The neutrophil-lymphocyte ratio (Neutrophils/leukocytes-neutrophils) (NLR) and the LDH levels have been correlated in multiple studies with the response to immunotherapy in different tumors. Based on these two variables, the LIPI index was developed and was validated in non-small cell lung cancer (NSCLC) as a predictor of response to immunotherapy.Our study proposes the validation of LIPI index and NLR in SLCL, treated with first line (1L) with atezolizumab plus chemotherapy in our population.