生物
营养感应
细胞生物学
细胞代谢
细胞
细胞生长
新陈代谢
信号转导
细胞信号
有机体
滞育
代谢途径
生物化学
遗传学
生态学
幼虫
作者
Trevor S. Tippetts,Matthew Sieber,Ashley Solmonson
出处
期刊:Development
[The Company of Biologists]
日期:2023-10-15
卷期号:150 (20)
被引量:7
摘要
ABSTRACT Metabolism is crucial for development through supporting cell growth, energy production, establishing cell identity, developmental signaling and pattern formation. In many model systems, development occurs alongside metabolic transitions as cells differentiate and specialize in metabolism that supports new functions. Some cells exhibit metabolic flexibility to circumvent mutations or aberrant signaling, whereas other cell types require specific nutrients for developmental progress. Metabolic gradients and protein modifications enable pattern formation and cell communication. On an organism level, inadequate nutrients or stress can limit germ cell maturation, implantation and maturity through diapause, which slows metabolic activities until embryonic activation under improved environmental conditions.
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