An elevated likelihood of stroke, ischemic heart disease, or heart failure in individuals with gout: a longitudinal follow-up study utilizing the National Health Information database in Korea

医学 心力衰竭 危险系数 痛风 冲程(发动机) 内科学 比例危险模型 置信区间 疾病 心脏病学 人口 队列 物理疗法 环境卫生 机械工程 工程类
作者
Ho Suk Kang,Na-Eun Lee,Dae Myoung Yoo,Kyeong Min Han,Ji Yeon Hong,Hyo Geun Choi,Hyun Lim,Joo‐Hee Kim,Ji Hee Kim,Seong-Jin Cho,Eun Sook Nam,Ha Young Park,Nan Young Kim,Sung Uk Baek,Joo Yeon Lee,Mi Jung Kwon
出处
期刊:Frontiers in Endocrinology [Frontiers Media SA]
卷期号:14 被引量:4
标识
DOI:10.3389/fendo.2023.1195888
摘要

Accumulating evidence from other countries indicates potential associations between gout and cardiovascular diseases; however, the associations of gout with cardiovascular diseases, particularly stroke, ischemic heart disease, and heart failure, remain ambiguous in the Korean population. We hypothesized that individuals with gout are at a higher likelihood of stroke, ischemic heart disease, or heart failure. This study expands upon previous research by ensuring a comparable baseline between patient and control groups and analyzing 16 years of data derived from an extensive healthcare database.We selected 22,480 patients with gout and 22,480 control individuals from the Korean National Health Insurance Service-Health Screening Cohort database (2002-2019), and matched them at a 1:1 ratio according to sex, age, income, and residence. A Cox proportional hazard model with weighted overlap was employed to examine the relationship between gout and the risk of stroke, ischemic heart disease, or heart failure after adjustment for several covariates.The incidences of stroke, ischemic heart disease, or heart failure in participants with gout were slightly higher than those in controls (stroke: 9.84 vs. 8.41 per 1000 person-years; ischemic heart disease: 9.77 vs. 7.15 per 1000 person-years; heart failure: 2.47 vs. 1.46 per 1000 person-years). After adjustment, the gout group had an 11% (95% confidence interval [CI] = 1.04-1.19), 28% (95% CI = 1.19-1.37), or 64% (95% CI = 1.41-1.91) higher likelihood of experiencing stroke, ischemic heart disease, or heart failure, respectively, than the control group.The present findings suggest that individuals with gout in the Korean population, particularly those aged ≥ 60 years, were more likely to have stroke, ischemic heart disease, or heart failure.
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