Flurpiridaz F-18 PET Myocardial Perfusion Imaging in Patients With Suspected Coronary Artery Disease

医学 冠状动脉疾病 心肌灌注成像 灌注 内科学 灌注扫描 疾病 放射科 心脏病学
作者
Jamshid Maddahi,Denis Agostini,Timothy M. Bateman,Jeroen J. Bax,Rob Beanlands,Daniel S. Berman,Sharmila Dorbala,Ernest Garcia,James A. Feldman,Gary V. Heller,Juhani Knuuti,Pedro Martinez‐Clark,Matthieu Pelletier‐Galarneau,Benjamin Shepple,Nagara Tamaki,François Tranquart,James E. Udelson
出处
期刊:Journal of the American College of Cardiology [Elsevier BV]
卷期号:82 (16): 1598-1610 被引量:26
标识
DOI:10.1016/j.jacc.2023.08.016
摘要

Flurpiridaz F-18 (flurpiridaz) is a novel positron emission tomography (PET) myocardial perfusion imaging tracer. The purpose of this study was to further assess the diagnostic efficacy and safety of flurpiridaz for the detection and evaluation of coronary artery disease (CAD) defined as ≥50% stenosis by quantitative invasive coronary angiography (ICA). In this second phase 3 prospective multicenter clinical study, 730 patients with suspected CAD from 48 clinical sites in the United States, Canada, and Europe were enrolled. Patients underwent 1-day rest/stress flurpiridaz PET and 1- or 2-day rest-stress Tc-99m–labeled single photon emission computed tomography (SPECT) before ICA. PET and SPECT images were read by 3 experts blinded to clinical and ICA data. A total of 578 patients (age 63.7 ± 9.5 years) were evaluable; 32.5% were women, 52.3% had body mass index ≥30 kg/m2, and 33.6% had diabetes. Flurpiridaz PET met the efficacy endpoints of the study; its sensitivity and specificity were significantly higher than the prespecified threshold value by 2 of the 3 readers. The sensitivity of flurpiridaz PET was higher than SPECT (80.3% vs 68.7%; P = 0.0003) and its specificity was noninferior to SPECT (63.8% vs 61.7%; P = 0.0004). PET area under the receiver-operating characteristic curves were higher than SPECT in the overall population (0.80 vs 0.68; P < 0.001), women, and obese patients (P < 0.001 for both). Flurpiridaz PET was superior to SPECT (P < 0.001) for perfusion defect size/severity evaluation, image quality, diagnostic certainty, and radiation exposure. Flurpiridaz PET was safe and well tolerated. This second flurpiridaz PET myocardial perfusion imaging trial shows that flurpiridaz has utility as a new tracer for CAD detection, specifically in women and obese patients. (An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz [18F] Injection PET MPI in the Detection of Coronary Artery Disease [CAD]; NCT03354273)
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Lucas应助大喵采纳,获得10
刚刚
wly发布了新的文献求助10
1秒前
Sky36001完成签到,获得积分10
2秒前
xu完成签到 ,获得积分10
2秒前
可爱的函函应助lingo采纳,获得10
4秒前
Sky36001发布了新的文献求助10
5秒前
9秒前
咖啡龙完成签到,获得积分20
10秒前
斯文钢笔完成签到 ,获得积分10
10秒前
10秒前
10秒前
11秒前
12秒前
12秒前
裴向雪发布了新的文献求助10
12秒前
然大宝完成签到,获得积分10
14秒前
黑色土豆发布了新的文献求助10
15秒前
大喵发布了新的文献求助10
16秒前
子非鱼发布了新的文献求助10
16秒前
Amon发布了新的文献求助10
18秒前
帅男发布了新的文献求助10
18秒前
19秒前
19秒前
田様应助keyantong采纳,获得10
20秒前
北风发布了新的文献求助10
21秒前
22秒前
漂亮白枫发布了新的文献求助10
25秒前
白许四十完成签到,获得积分10
27秒前
27秒前
28秒前
阳立宇完成签到,获得积分10
29秒前
wanci应助漂亮白枫采纳,获得10
29秒前
打打应助科研通管家采纳,获得10
30秒前
科研通AI2S应助科研通管家采纳,获得10
30秒前
CipherSage应助科研通管家采纳,获得10
30秒前
Hello应助科研通管家采纳,获得10
30秒前
某某辣酱发布了新的文献求助10
30秒前
C_Cppp发布了新的文献求助10
31秒前
33秒前
猪蹄发布了新的文献求助10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989797
求助须知:如何正确求助?哪些是违规求助? 3531910
关于积分的说明 11255394
捐赠科研通 3270563
什么是DOI,文献DOI怎么找? 1805008
邀请新用户注册赠送积分活动 882157
科研通“疑难数据库(出版商)”最低求助积分说明 809190