Delta Radiomics Model Predicts Lesion-Level Responses to Tyrosine Kinase Inhibitors in Patients with Advanced Renal Cell Carcinoma: A Preliminary Result

医学 接收机工作特性 肾细胞癌 曲线下面积 病变 放射科 队列 回顾性队列研究 肾透明细胞癌 内科学 肿瘤科 核医学 病理
作者
Yahong Chen,Enyu Yuan,Guangxi Sun,Bin Song,Jin Yao
出处
期刊:Journal of Clinical Medicine [Multidisciplinary Digital Publishing Institute]
卷期号:12 (4): 1301-1301 被引量:1
标识
DOI:10.3390/jcm12041301
摘要

This study aimed to develop and internally validate computed tomography (CT)-based radiomic models to predict the lesion-level short-term response to tyrosine kinase inhibitors (TKIs) in patients with advanced renal cell carcinoma (RCC).This retrospective study included consecutive patients with RCC that were treated using TKIs as the first-line treatment. Radiomic features were extracted from noncontrast (NC) and arterial-phase (AP) CT images. The model performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration curve, and decision curve analysis (DCA).A total of 36 patients with 131 measurable lesions were enrolled (training: validation = 91: 40). The model with five delta features achieved the best discrimination capability with AUC values of 0.940 (95% CI, 0.890‒0.990) in the training cohort and 0.916 (95% CI, 0.828‒1.000) in the validation cohort. Only the delta model was well calibrated. The DCA showed that the net benefit of the delta model was greater than that of the other radiomic models, as well as that of the treat-all and treat-none criteria.Models based on CT delta radiomic features may help predict the short-term response to TKIs in patients with advanced RCC and aid in lesion stratification for potential treatments.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
Trueman发布了新的文献求助10
1秒前
末末完成签到,获得积分10
2秒前
Expelliarmus发布了新的文献求助10
2秒前
无畏发布了新的文献求助10
3秒前
慕青应助Hayat采纳,获得20
3秒前
赘婿应助VV采纳,获得10
4秒前
研究牲发布了新的文献求助10
4秒前
5秒前
思源应助Trueman采纳,获得10
6秒前
hh哈哈完成签到,获得积分10
7秒前
毕业就集采的苦命人完成签到 ,获得积分10
8秒前
8秒前
善学以致用应助魏家乐采纳,获得10
9秒前
研究牲完成签到,获得积分10
11秒前
乔qiao完成签到 ,获得积分10
11秒前
11秒前
Picky完成签到,获得积分10
12秒前
glitter完成签到,获得积分10
12秒前
SciGPT应助哈哈哈采纳,获得10
13秒前
Fein_W完成签到,获得积分10
13秒前
温柔雪兰完成签到,获得积分10
13秒前
地球观光客完成签到,获得积分10
13秒前
14秒前
无花果应助火星上书本采纳,获得10
14秒前
zha完成签到,获得积分10
14秒前
14秒前
14秒前
研友_VZG7GZ应助澡雪采纳,获得10
15秒前
16秒前
philospipi应助个性的向秋采纳,获得10
16秒前
gyl发布了新的文献求助10
17秒前
CodeCraft应助太陽采纳,获得10
18秒前
18秒前
charlins发布了新的文献求助10
18秒前
father完成签到,获得积分10
19秒前
zzz发布了新的文献求助10
19秒前
20秒前
20秒前
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975816
求助须知:如何正确求助?哪些是违规求助? 3520159
关于积分的说明 11201128
捐赠科研通 3256541
什么是DOI,文献DOI怎么找? 1798347
邀请新用户注册赠送积分活动 877539
科研通“疑难数据库(出版商)”最低求助积分说明 806426